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Protein GSK3β Offers New Angle on Overcoming Melanoma Drug Resistance

April 11, 2025

Inhibitors of GSK3β reduce the cell viability of BRAFi-resistant melanoma cell lines and thus may holds promise as a novel strategy to overcome BRAFi resistance and melanoma progression.”BUFFALO, NY -... read more

Oncotarget

AI That Measures Its Own Uncertainty Could Improve Liver Cancer Detection

April 8, 2025

These advancements, by providing more reliable and efficient diagnostic tools, may significantly impact clinical practice by addressing the ever-growing clinical demand and work pressure, while maintaining interpretability and clinical relevance.”... read more

Oncotarget

Triple Therapy Slows Glioblastoma Growth and Extends Survival in Preclinical Study

April 4, 2025

Our findings demonstrate for the first time that IRT therapy combining ONC201 or ONC206 with RT and TMZ may be a safe and effective therapeutic strategy for GBM.”BUFFALO, NY -... read more

Oncotarget

NSD2 Gene Drives Cancer Cell Identity in Multiple Myeloma

April 2, 2025

Our findings suggest a role for NSD2 in maintaining MM cell identity, with potential implications for future therapeutic strategies based on targeting of NSD2.”BUFFALO, NY - April 2, 2025 – A... read more

Oncotarget

Single Protein Mimics Retinoic Acid Therapy to Help Leukemia Cells Mature

March 31, 2025

This study reveals that the expression of the Src-family kinase (SFK), FGR, alone can induce cell differentiation similar to RA.”BUFFALO, NY - March 31, 2025 – A new research paper was... read more

Oncotarget

Why Some Breast Cancer Treatments Stop Working

March 25, 2025

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized medicine and improving clinical outcomes.”BUFFALO, NY - March 25, 2025 – A... read more