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Lessons from ACDC-RP Trial: Designing Neoadjuvant Therapy Trials for Prostatectomy

October 7, 2024

While the ACDC-RP trial adds to the litany of negative trials in this disease space, there are key takeaways from this trial that can inform future clinical trial design.”BUFFALO,... read more

Oncotarget

Exploring UBA1 Dysfunction in VEXAS Syndrome and Cancer

October 3, 2024

Ultimately, a thorough grasp of the pathogenesis of VEXAS, from genetic mutations to clinical manifestations, will be pivotal in devising safe and effective therapeutic strategies to fight this challenging disease.”... read more

Oncotarget

FOXM1 and PD-L1 in CDK4/6-MEK Resistance in Nerve Tumors

October 1, 2024

We suggest that future therapeutic strategies targeting the oncogenic network of CDK4/6, MEK, PD-L1, and FOXM1 represent exciting future treatment options for MPNST patients.”BUFFALO, NY- October 1, 2024 –... read more

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The Role of Artificial Intelligence in Advancing Intratumoral Immunotherapy

September 19, 2024

We explore how integrating these technologies could revolutionize personalized oncology.”BUFFALO, NY- September 19, 2024 – A new editorial was published in Oncotarget's Volume 15 on September 17, 2024, entitled, “The... read more

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ISR Activation & Apoptosis via HRI Kinase by PG3 and Other p53 Cancer Therapies

September 18, 2024

Our results provide unique insights into the mechanism of action of PG3 as a novel cancer therapeutic targeting p53 pathway-like tumor suppression.”BUFFALO, NY- September 18, 2024 – A new research... read more

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Targeting CD47/SIRPα “Do Not Eat Me” Axis: Advances and Challenges in Cancer Therapy

September 11, 2024

Numerous phagocytosis checkpoints and ‘do not eat me’ signals (i.e., CD47, CD24, MHC-I, PD-L1, STC1, and GD2) have recently been recognized as potential therapeutic targets.”BUFFALO, NY- September 11,... read more

Oncotarget

Next-Gen Vaccines Offer New Hope Against Glioblastoma

September 9, 2024

Vaccines have been considered a promising approach for GBM for many years.”BUFFALO, NY- September 9, 2024 – A new editorial was published in Oncotarget's Volume 15 on August 5, 2024,... read more

Oncotarget

Generative AI in Cancer Imaging: Revolutionizing Detection & Diagnosis

September 6, 2024

This editorial explores its impact on expanding datasets, improving image quality, and enabling predictive oncology.”BUFFALO, NY- September 6, 2024 – A new editorial was published in Oncotarget's Volume 15 on... read more

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Case for Inflammatory Memory for Hematopoietic Stem and Progenitor Cells in AML Niche

September 5, 2024

In this research perspective, we discuss recent work from our lab describing an active role of HSPCs in AML and the potential implications.”BUFFALO, NY- September 5, 2024 – A new... read more