Category: Oncotarget

Oncotarget News

Oncotarget | Targeted Elastin-like Polypeptide Fusion Protein for Near-infrared Imaging of Human and Canine Urothelial Carcinoma

September 8, 2022

We have developed a peptide-based NIR probe, Cy5.5-N24-EGF, that shows high EGFR-specific binding specificity in canine and human UC in vitro and ex vivo.”BUFFALO, NY- September 8, 2022 –... read more

Oncotarget

Oncotarget | Kinase Activity in Renal Cell Carcinoma, Benign Renal Tissue and in Response to Tyrosine Kinase Inhibitors

August 17, 2022

Thus, the presented findings might provide options to select the most promising TKI for individual RCC patients prior to initiation of TKI-therapies.”BUFFALO, NY- August 17, 2022 – A new research... read more

Oncotarget

Oncotarget | Glypican-3 (GPC3) Associated With MCPyV-negative Status and Impaired Outcome in Merkel Cell Carcinoma

August 11, 2022

High prevalence of surface GPC3 makes it a putative drug target.”BUFFALO, NY- August 11, 2022 – A new research paper was published in Oncotarget on August 3,... read more

Oncotarget

Oncotarget | A Novel Mechanism of Regulation of the Oncogenic Transcription Factor GLI3 by Toll-like Receptor Signaling

August 9, 2022

These results increase our understanding of the signaling molecules that can regulate GLI3 in a HH-independent manner.”BUFFALO, NY- August 9, 2022 – A new research paper was published in Oncotarget... read more

Oncotarget

Oncotarget | Chemoradiation Alters PD-L1, CD8+ TILs and Mucin in Rectal Cancer

August 2, 2022

In conclusion, our study provides further data on the immunologic impact of nCRT in rectal cancer.”BUFFALO, NY- August 2, 2022 – A new research paper was published in ... read more

Oncotarget

Oncotarget | CUDC907 Promotes Apoptosis of NF2 Schwannoma Cells

July 26, 2022

CUDC907 has cytotoxic activity in NF2 schwannoma models and primary VS cells and is a candidate for clinical trials.”BUFFALO, NY- July 26, 2022 – A new research paper was... read more

Oncotarget

Oncotarget | Predicting Cancer Immunotherapy Response From Gut Microbiomes Using Machine Learning Models

July 19, 2022

Findings demonstrate how machine learning models can reveal microbiome-immunotherapy interactions that may ultimately improve cancer patient outcomes.”BUFFALO, NY- July 19, 2022 – A new research paper was published in&... read more

Oncotarget

Behind the Study: Molecular Characterization of Lung Carcinomas Expressing KK-LC-1

July 11, 2022

Dr. Robert Hsu from the University of Southern California, Norris Comprehensive Cancer Center, describes a recent research paper he co-authored that was published by Oncotarget, entitled, “Molecular characterization of... read more

Oncotarget

Oncotarget | Role of germline variants in the metastasis of breast carcinomas

July 7, 2022

We found several gene candidates through which the host’s genetic makeup contributes to metastasis.”BUFFALO, NY- July 7, 2022 – A new research paper was published in Oncotarget on June... read more

Oncotarget

Oncotarget | Continuous Treatment With Abemaciclib Leads to Sustained and Efficient Inhibition of Breast Cancer Cell Proliferation

July 6, 2022

These preclinical results support the unique efficacy and safety profile of abemaciclib observed in clinical trials.”BUFFALO, NY- July 6, 2022 – Researchers from Eli Lilly and Company ... read more