Breast Cancer Archives | Page 4 of 6

Oncotarget News

Figure 3: Cytokine expression and cell viability upon mRNA silencing of STAT3 isoforms

Differential Silencing of STAT3 Isoforms Leads to Changes in STAT3 Activation

April 26, 2023

Our study emphasizes the importance of distinguishing between STAT3α and STAT3β proteins and their active forms when discussing STAT3-related cancer diagnosis and therapy.”BUFFALO, NY- April 26, 2023 – A new... read more

Figure 1: Tumor necroptosis promotes metastasis of breast cancer by suppressing anti-tumor immunity.

Oncotarget

Tumor Necroptosis Promotes Metastasis by Modulating Tumor-Host Immunity

April 25, 2023

we found that blocking necroptosis leads to the inhibition of metastasis in mouse breast cancer models [...]”BUFFALO, NY- April 24, 2023 – A new editorial paper was published in Oncotarget's Volume... read more

Figure 2: Active pharmacological intervention trials in TNBC.

Oncotarget

Crosstalk Between Triple Negative Breast Cancer and Microenvironment

April 10, 2023

the study of immunotherapy for treating triple negative breast cancer might still be at its early stages of development but is full of future promise.” BUFFALO, NY- April 10,... read more

Figure 1: The molecular mechanism(s) of how Wnt5a signaling could (i) induce ROR1 and cortactin association, tyrosine phosphorylation of cortactin, and activation of RhoA, (ii) enhance F-actin polymerization, and (iii) subsequently promote migration or metastasis of cancer cells.

Oncotarget

Impact of Cortactin in Cancer Progression

April 4, 2023

Cortactin (also known as EMS1 or CTTN) is expressed broadly in a variety of cancers [...]” BUFFALO, NY- April 4, 2023 – A new editorial paper was published in Oncotarget's Volume... read more

Figure 5: NSL-YHJ-2-27 suppresses cancer cell migration and invasion.

Oncotarget

Oncotarget | Polyisoprenylated Cysteinyl Amide Inhibitors Deplete G-Proteins in Cancer Cells

March 28, 2023

mutations in G-proteins have been associated in the progress of several cancers [...]” BUFFALO, NY- March 28, 2023 – A new research paper was published in Oncotarget's Volume 14 on March... read more

Figure 1: Mechanism of action of MTAP along with downstream effects from its loss.

Oncotarget

Oncotarget | MTAP Loss in Metastatic Breast Cancer Patients: Genomic Landscape

March 14, 2023

In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” BUFFALO, NY- March 14,... read more

Oncotarget

Oncotarget | Extreme Phenotype Approach Identifies Rare ATR Variants as Potential Male Breast Cancer Susceptibility Alleles

February 21, 2023

Basic functions of ATR classify it in the category of tumor suppressor genes but further studies show that its role is more complex in the context of cancer.” BUFFALO,... read more

Figure 4: Wnt pathway expression in tumors from NeuT/ATTAC mice.

Oncotarget

Oncotarget | Resistance of MMTV-NeuT/ATTAC Mice to Anti-PD-1 Immune Checkpoint Therapy is Associated With Macrophage Infiltration and Wnt Pathway Expression

January 5, 2023

One of the impediments to successful cancer therapy is the heterogeneity and cellular plasticity of the tumor and TME [22, 23].” BUFFALO, NY- January 5, 2023 – A new research... read more

“Association of fall rate and functional status by APOE genotype in cancer survivors after exercise intervention.”

Oncotarget

Behind the Study: APOE Genotype Determines Cancer Patients Most Likely to Benefit From Exercise

December 13, 2022

Dr. Kerri Winters-Stone and Dr. Jacob Raber from Oregon Health and Science University, describe a research paper they co-authored that was published by Oncotarget in Volume 13, entitled, “Association of... read more

Oncotarget

Oncotarget | Association of Fall Rate and Functional Status by APOE Genotype in Cancer Survivors After Exercise Intervention

November 21, 2022

This is the first examination of the relationship among exercise, apoE genotype, and side effects and symptoms of cancer in a subset of older female cancer survivors participating in a... read more