cancer research Archives

Oncotarget News

HER2-Low Breast Cancer: Genomic Insights and Evolving Treatment Paradigms

January 22, 2025

Human epidermal growth factor receptor 2 (HER2)-low breast cancer has recently emerged as a new clinical subtype of breast cancer, benefiting from treatment with novel anti-HER2 antibody-drug conjugates.”BUFFALO,... read more

Oncotarget

Anti-Correlation Between KLRG1 and PD-1 in Tumor CD8 T Cells

January 21, 2025

The anti-correlation of PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells suggests the potential for combination therapy supra-additive benefits of anti-PD-1 and anti-KLRG1 therapies.”BUFFALO, NY - January... read more

Oncotarget

Pitfalls of FDA-Approved Germline Cancer Predisposition Tests

December 30, 2024

The FDA approval on September 29, 2023, for 'class III de novo' blood tests to assess hereditary cancer risk make widely available tests that may be obtained through a Direct... read more

Oncotarget

Breakthroughs in Cell-Penetrating Monoclonal Antibody Therapies

December 11, 2024

Monoclonal antibodies (mAb) have emerged as a promising tool in advancing personalized medicine.”BUFFALO, NY - December 11, 2024 – A news feature on the research paper “Next-generation cell-penetrating antibodies for tumor... read more

Oncotarget

B7-H4 as a Therapeutic Target in Adenoid Cystic Carcinoma

December 4, 2024

These results provide a robust rationale to investigate B7-H4 as a therapeutic target for B7-H4 expressing ACC.”BUFFALO, NY - December 4, 2024 – A new editorial was published in Oncotarget's Volume... read more

Oncotarget

Mesenchymal Stem Cells in Cancer Immunotherapy: Promises and Challenges

December 3, 2024

MSCs hold great promise as a therapeutic tool in cancer immunotherapy due to their immunomodulatory properties, tumor-homing abilities, and potential as carriers for delivering therapeutic agents.”BUFFALO, NY - December 3,... read more

Oncotarget

Persistence Landscapes: A Path to Unbiased Radiological Interpretation

November 27, 2024

Persistence landscapes, a sophisticated tool from topological data analysis, offer a promising approach to address biases in radiological interpretation and AI model development.”BUFFALO, NY - November 27, 2024 – A new... read more

Oncotarget

Visualizing Radiological Data Bias with Persistence Images

November 25, 2024

Persistence images represent a powerful new tool in our ongoing efforts to visualize, understand, and mitigate biases in radiological data interpretation and AI model development.”BUFFALO, NY - November 25, 2024 –... read more

Oncotarget

Persistence Barcodes: Reducing Bias in Radiological Analysis

November 20, 2024

Persistence barcodes emerge as a promising tool in radiological analysis, offering a novel approach to reduce bias and uncover hidden patterns in medical imaging.”BUFFALO, NY - November 20, 2024 – A... read more

Oncotarget

Behind the Study: DLL3, ASC1, TTF-1 & Ki-67 in Precision Medicine for SCLC

November 18, 2024

Samuel Silva from the Department of Pathology at Federal University of Ceará in Fortaleza, Brazil, discusses a research paper he co-authored that was published in Oncotarget Volume 15, titled, “Relationship... read more