cancer research Archives | Page 11 of 29

Oncotarget News

Risk Factors for Long-Term Arm Morbidities Following Breast Cancer Treatments: A Systematic Review

December 11, 2023

This review revealed 29 primary risk factors associated with arm morbidity after breast cancer treatment.”BUFFALO, NY- December 11, 2023 – A new review paper was published in Oncotarget's Volume 14... read more

Figure 3: Patient examples of inverse correlation of BCMA and FLC changes during course of therapy.

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BCMA+ EV Levels Correlate With Myeloma Response to Belantamab-Mafodotin

December 6, 2023

Measurement of BCMA-EV can thus help in identifying resistance mechanisms and side effects of BCMA targeted therapies in future studies.”BUFFALO, NY- December 6, 2023 – A new research paper was... read more

Figure 5: The mediators of mitochondrial biogenesis are required for cancer spread. "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells"

Oncotarget

Osteopontin Induces Mitochondrial Biogenesis in Deadherent Cancer Cells

December 4, 2023

Here, we study the induction of mitochondrial biogenesis by Osteopontin variants in deadherent breast tumor cells.”BUFFALO, NY- December 4, 2023 – A new research paper was published in Oncotarget's Volume... read more

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The Double-Edge Sword of CRISPR Application for In Vivo Studies

November 28, 2023

The Achilles’ heel of CRISPR application is the delivery of sgRNA/Cas9 to the desired tissues.”BUFFALO, NY- November 28, 2023 – A new editorial paper was published in Oncotarget's Volume... read more

Oncotarget

Targeting Ras With Protein Engineering

November 27, 2023

While Ras’s relationship to cancer has been long established [37], it has been considered an undruggable target for many years.”BUFFALO, NY- November 27, 2023 – A recent review paper... read more

Figure 2: The spectrum of pathogenic variants in the early-onset breast cancer cohort.

Oncotarget

Genetic Predisposition to Early Breast Cancer in Kazakh Women

November 22, 2023

Our study may reveal previously uncharacterized population-specific variants that may increase the risk of BC in the Kazakh population.”BUFFALO, NY- November 22, 2023 – A new research paper was published... read more

Figure 1: Chromatin landscape of the glioma GWAS locus rs55705857 in the melanocyte lineage.

Oncotarget

Predicting the Molecular Functions of Regulatory Genetic Variants Associated With Cancer

November 20, 2023

Effectively integrating these rich resources with GWAS results will continue to help prioritize causative inherited genetic variants and improve our molecular understanding of disease etiology [...]”BUFFALO, NY- November 20, 2023 –... read more

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Obesity Paradox and Lung Cancer, Metformin-based Therapeutic Opportunity?

November 15, 2023

These findings suggest a strong sensitization by the addition of metformin in obese population, suggesting that biochemical and molecular differences influence the treatment response.”BUFFALO, NY- November 15, 2023 – A... read more

Oncotarget

C/EBPβ Cooperates With MYB to Maintain the Oncogenic Program of AML Cells

November 13, 2023

This makes C/EBPβ an interesting pro-oncogenic player in AML, worthy of further studies.”BUFFALO, NY- November 13, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on... read more

Figure 1: Graphical illustration of the main findings from Pfeiffer et al., Cancer Research, 2022. Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

Oncotarget

Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

November 8, 2023

In summary, this study reveals a molecular escape mechanism of mutated RTK-driven leukemic cells from SHP2 allosteric inhibition [...]”BUFFALO, NY- November 8, 2023 – A new editorial paper was published in... read more