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Oncotarget News

Figure 1: Graphical illustration of the main findings from Pfeiffer et al., Cancer Research, 2022. Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

November 8, 2023

In summary, this study reveals a molecular escape mechanism of mutated RTK-driven leukemic cells from SHP2 allosteric inhibition [...]”BUFFALO, NY- November 8, 2023 – A new editorial paper was published in... read more

Oncotarget

The Uncharted Role of HER2 Mutant Alleles in Breast Cancer

November 6, 2023

Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].”BUFFALO, NY- November 6, 2023 – A new editorial paper was... read more

Figure 1: An overview of the endocannabinoid pathway and molecules tested in this study. breast cancer

Oncotarget

FAAH Inhibition Ameliorates Murine Breast Cancer

November 1, 2023

Besides being the most common, breast cancer is also a leading cause of cancer death in women worldwide.”BUFFALO, NY- November 1, 2023 – A new research paper was published in... read more

Figure 1: Mechanisms involved in regulation of tumor progression by neutrophil PAD4.

Oncotarget

Neutrophil PAD4: How Does it Function in Cancer Beyond Promoting NETosis?

October 30, 2023

This will open a novel therapeutic approach for targeting PMN-MDSC in cancer.”BUFFALO, NY- October 30, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on March 24,... read more

Figure 4: Loss of p53 predisposes to mammary tumors in mice and in women, but penetrance varies among individuals.

Oncotarget

Genetic Modifiers of p53 and Their Potential in Breast Cancer Therapies

October 25, 2023

p53 acts in concert with other genes that alter the penetrance of tumor phenotypes and the modifiers differ among tissues.”BUFFALO, NY- October 25, 2023 – A new editorial perspective was... read more

Figure 3: (A) Simulations of the reaction-diffusion model (solid lines) and measured follicle length (solid circles). (B) The function a(x) describing the pro-survival factor released by the regenerative stem cell pool. The inset shows a schematic of a hair follicle regressing slower as it gets shorter and closer to higher values of the pro-survival factor modeled with the function a(x) and released by the regenerative stem cells.

Oncotarget

Apoptotic Cells May Drive Cell Death in Hair Follicles During Regression Cycle

October 23, 2023

Revealing the stem cell niche self-renewal dynamics is important not only for understanding tissue homeostasis but also for understanding the initiation of cancer [7].”BUFFALO, NY- October 23, 2023 – A... read more

Figure 1: Working model for TME-mediated nuclear softening via LINC and emerin.

Oncotarget

The Nuclear Envelope and Breast Cancer Metastasis

October 18, 2023

ascertaining the mechanisms that enable metastatic spread can be transformational in our understanding of tumor progression and for future development of therapeutic interventions.”BUFFALO, NY- October 18, 2023 – A new... read more

Oncotarget

GBP3-STING Interaction in Glioblastoma Coordinates Poor Response to Temozolomide

October 17, 2023

The paper revealed a critical role of GBP3 involving multiple [temozolomide] resistance mechanisms.”BUFFALO, NY- October 17, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on May... read more

Oncotarget

Behind the Study: HER3: A Vital Target in Cancer Treatment

October 12, 2023

Dr. Omkar Desai from the Department of Surgery at Case Western Reserve University and University Hospitals Cleveland Medical Center, describes a research perspective he co-authored with Dr. Rui Wang that... read more

Oncotarget

Suppression of Cancer Stemness and Drug Resistance via BRAF/EGFR/MEK Inhibition in Colorectal Cancer Cells

October 11, 2023

our approach enables mechanistic studies of drug resistance with 3D cultures of primary cancer cells to develop and test treatments that suppress cancer [...].”BUFFALO, NY- October 11, 2023 – A new... read more