cancer research Archives | Page 16 of 28

Oncotarget News

Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression

BORIS Gene Mutation and Expression: Link to Breast Cancer Progression

June 5, 2023

The current study analyzed the correlation between BORIS mutations and the expression of the protein in breast cancer cases.”BUFFALO, NY- June 5, 2023 – A new research paper was published... read more

Figure 1: MALAT1-ASO specifically targets MALAT1-lncRNAs.

Oncotarget

Deconstructing the Role of MALAT1 in MAPK-Signaling in Melanoma

May 30, 2023

In this study, we present novel transcriptional dependencies between MALAT1 and MAPK-pathway-associated genes in melanoma.”BUFFALO, NY- May 30, 2023 – A new research paper was published in Oncotarget's Volume 14... read more

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Behind the Study: Molecular Dialogue Between Tumor Cells and Fibroblasts

May 25, 2023

Dr. Gopal C. Kundu from KIIT Deemed to be University in Odisha, India, describes a recent editorial he co-authored that was published by Oncotarget in Volume 14, entitled, “The molecular... read more

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HER3: Survival Pathway and Therapeutic Target in Metastatic Colorectal and Pancreatic Cancer

May 24, 2023

we discovered that the surrounding liver EC microenvironment plays a key role in activating HER3 and promoting cell survival in mCRC and mPDAC [...].”BUFFALO, NY- May 24, 2023 – A new... read more

Figure 7: Schematic demonstrating the role of GPR141 in mediating breast cancer development and progression.

Oncotarget

GPR141 Regulates Breast Cancer Progression via Oncogenic Mediators and The p-mTOR/p53 Axis

May 22, 2023

This research uncovers GPR141 as a stimulator of breast tumorigenesis and metastasis, making it a candidate target for breast cancer therapeutics.”BUFFALO, NY- May 22, 2023 – A new research paper... read more

Figure 1: Inhibitors of mitochondrial respiration.

Oncotarget

Targeting Cellular Respiration as a Therapeutic Strategy in Glioblastoma

May 19, 2023

Here, we provide a brief overview of the status quo of targeting mitochondrial energy metabolism in glioblastoma and highlight a novel combination therapy.”BUFFALO, NY- May 19, 2023 – A new... read more

Figure 2: Polyclonal, Clonal and Restricted Repertoire Phenotypes in Clonality Testing.

Oncotarget

Automated, Accurate Reporting for NGS-Based Clonality Testing

May 16, 2023

we have developed a fully automated calling algorithm for determining B and T cell clonality from NGS [next-generation sequencing] data, with greater sensitivity than previously developed models.”BUFFALO, NY- May... read more

Figure 3: Combined analysis of kinase expression in tumors with cell line dependency to identify new gene targets. therapeutic targeting

Oncotarget

Using Cancer Proteomics Data to Identify Gene Candidates for Therapeutic Targeting

May 10, 2023

we consider some public molecular resources, including proteomics datasets, that may be leveraged to help identify gene candidates for therapeutic targeting in cancer.”BUFFALO, NY- May 10, 2023 – A new... read more

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Behind the Study: Role of Biomarkers in Management of Lumps in the Breast

May 10, 2023

Dr. Georg F. Weber, from the University of Cincinnati Academic Health Center, describes a recent research perspective he authored that was published by Oncotarget in Volume 14, entitled, “Crossroads: the... read more

Figure 2: Comparison of human LY6 gene expression in normal uterine tissue (n = 146) to expression in uterine corpus endometrial carcinoma (n = 547).

Oncotarget

LY6 Gene Family: Potential Tumor Antigens and Prognostic Biomarkers in Endometrial Cancer

May 8, 2023

Importantly, the expression of several LY6 genes is elevated in UCEC [uterine corpus endometrial carcinoma] when compared to the expression in normal uterine tissue.”BUFFALO, NY- May 8, 2023 – A... read more