Tag: cell death

Oncotarget News

ISR Activation & Apoptosis via HRI Kinase by PG3 and Other p53 Cancer Therapies

September 18, 2024

Our results provide unique insights into the mechanism of action of PG3 as a novel cancer therapeutic targeting p53 pathway-like tumor suppression.”BUFFALO, NY- September 18, 2024 – A new research... read more

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death

Oncotarget

INT-1B3 miR-193a-3p Mimic Boosts T Cell Immunity and Induces Tumor Cell Death

August 5, 2024

INT-1B3 inhibited distant tumor metastasis and significantly prolonged survival.”BUFFALO, NY- August 5, 2024 – A new research paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, “INT-1B3,... read more

Figure 3: (A) Simulations of the reaction-diffusion model (solid lines) and measured follicle length (solid circles). (B) The function a(x) describing the pro-survival factor released by the regenerative stem cell pool. The inset shows a schematic of a hair follicle regressing slower as it gets shorter and closer to higher values of the pro-survival factor modeled with the function a(x) and released by the regenerative stem cells.

Oncotarget

Apoptotic Cells May Drive Cell Death in Hair Follicles During Regression Cycle

October 23, 2023

Revealing the stem cell niche self-renewal dynamics is important not only for understanding tissue homeostasis but also for understanding the initiation of cancer [7].”BUFFALO, NY- October 23, 2023 – A... read more