melanoma Archives | Oncotarget

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Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival

TCR CDR3s and Renalase-1 Linked to Increased Melanoma Survival

August 8, 2024

These findings indicate that renalase-1 is a potential antigen for TCR recognition in melanoma and could be considered as a target for immunotherapy.”BUFFALO, NY- August 8, 2024 – A new... read more

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Prognostic and Therapeutic Insights Into MIF, DDT, and CD74 in Melanoma

July 26, 2024

we present the first study to retrospectively evaluate differential gene expression of MIF, DDT, and relevant pathway markers in regard to clinical outcomes in patients with melanoma.”BUFFALO, NY- July... read more

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When Does a Melanoma Metastasize? Implications for Management

June 18, 2024

immunotherapy is more likely to be effective at eliminating metastatic disease if the tumor burden is low, making it more logical to treat patients with high-risk melanomas at the earliest... read more

Table 8: Control data for transfection efficiency of uveal melanoma cells

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GZ17-6.02 Kills PDX Isolates of Uveal Melanoma

May 22, 2024

The present studies demonstrated that GZ17-6.02 interacted with irreversible inhibitors of the EGF receptor and HER2 to kill uveal melanoma cells.”BUFFALO, NY- May 22, 2024 – A new research... read more

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A Macrophage is a Macrophage is a Macrophage—in Metastasis

August 23, 2023

We hope that these results will inform future attempts at anti-macrophage therapy and lead to better outcomes for patients in the not-too-distant future.” BUFFALO, NY- August 23, 2023 – A... read more

Figure 1: Combined targeting of SMO and BRD4 as a potential therapeutic strategy against melanoma.

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Novel Therapeutic Strategy Against Melanoma: Combined Targeting of Hedgehog Signaling and BRD4

July 19, 2023

This evidence strengthens the relevance of the findings by Pietrobono et al., shedding light on the potential application of SMO inhibitors in concert with BRD4 inhibitors.”BUFFALO, NY- July 19,... read more

Figure 1: MALAT1-ASO specifically targets MALAT1-lncRNAs.

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Deconstructing the Role of MALAT1 in MAPK-Signaling in Melanoma

May 30, 2023

In this study, we present novel transcriptional dependencies between MALAT1 and MAPK-pathway-associated genes in melanoma.”BUFFALO, NY- May 30, 2023 – A new research paper was published in Oncotarget's Volume 14... read more

Figure 7: Proposed mechanism of 15d-PMJ2-mediated apoptosis.

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Oncotarget | Calcium Signaling Induced by 15-deoxy-prostamide-J2 Promotes Cell Death by Activating…

January 12, 2023

The goal of the present study was to determine the therapeutic potential of 15d-PMJ2 against melanoma by gaining insight into molecular mechanisms underlying its apoptotic activity.”BUFFALO, NY- January 12,... read more

Figure 1: Demographic factors, comorbidities and therapy regime of the melanoma patients in percentage, age in years.

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Oncotarget | Impact of Covid-19 on Management of Patients With Metastatic Melanoma

January 11, 2023

In this study, we aimed to analyze our experience with patients suffering from Sars-CoV-2 infection while receiving treatment for metastatic melanoma.” BUFFALO, NY- January 11, 2023 – A new research... read more

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Behind the Study: PRAME Associated with Increased Metastatic Risk

June 7, 2021

Behind the Study is a series of transcribed videos from researchers elaborating on their recent oncology-focused studies published by Oncotarget. A new Behind the Study is released each... read more