Tag: pediatrics

Oncotarget News

Figure 1: (A) Canonical STAT3 activation pathway. (B) WP1066 and TTI-101, examples of small molecule STAT3 inhibitors that are cell penetrant.

STAT3 as a Target in H3K27M-mutant DMGs

October 9, 2023

Children diagnosed with these tumors have [...] a median survival of approximately 12 months.” BUFFALO, NY- October 9, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on... read more

Figure 2: Mechanism of radiation resistance in H3K27me3-deficient medulloblastoma.

Oncotarget

Epigenetically Guided Cancer Therapy: Targeting H3K27me3 Loss in Pediatric Brain Tumors

August 2, 2023

our discovery of H3K27me3 as an epigenetic marker of radiation resistance in medulloblastoma has a potential to open new therapeutic avenues [...]”BUFFALO, NY- August 2, 2023 – A new editorial paper... read more