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Oncotarget News

Figure 6: Overexpression of GPC1 increases proliferation of T24 cells.

Oncotarget | Attenuation of Cancer Proliferation by Suppression of Glypican-1

March 22, 2023

This study was designed to increase the knowledge on the potential of GPCs and in particular GPC1 as a biomarker in cancer diagnosis and prognosis.” BUFFALO, NY- March 22,... read more

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Oncotarget | Unlocking the Potential of Molecular-Driven Stratification of Osteosarcoma

March 20, 2023

We are very enthusiastic about these initiatives and the recent rate of discoveries in OSA, and hopeful that they will bring actionable targets for OSA.” BUFFALO, NY- March 20,... read more

Figure 1: Mechanism of action of MTAP along with downstream effects from its loss.

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Oncotarget | MTAP Loss in Metastatic Breast Cancer Patients: Genomic Landscape

March 14, 2023

In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” BUFFALO, NY- March 14,... read more

Figure 6: Synergistic/antagonistic combinations.

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Oncotarget | Selective Protection of Normal Cells From Chemotherapy, While Killing Drug-Resistant Cancer Cells

March 13, 2023

Selective protection of normal cells may transform therapy of cancer.” BUFFALO, NY- March 13, 2023 – A new review paper was published in Oncotarget's Volume 14 on March 11, 2023,... read more

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Oncotarget | Mitochondria Engage the Integrated Stress Response to Promote Tumor Growth

March 8, 2023

Overall, this research proposes a new paradigm on how AR-independent PCa can drive tumor traits by exploiting mitochondrial signaling pathways [...]” BUFFALO, NY- March 8, 2023 – A new editorial paper... read more

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Oncotarget | HALP Score: Prognostic Ability in Cancers – A Literature Review

March 6, 2023

In the last several years, the Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has emerged in the literature as a new prognostic biomarker [...]” BUFFALO, NY- March 6, 2023 – A new... read more

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Oncotarget | Unveiling the Non-canonical Functions of EZH2 in Prostate Cancer

March 3, 2023

In summary, both articles by Yi et al. emphasized the significance of non-canonical functions of EZH2 during PCa [prostate cancer] development [...]” BUFFALO, NY- March 3, 2023 – A new editorial... read more

Figure 1: Comparison of progression-free survival (A) and overall survival (B) between children (

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Oncotarget | WNT-pathway Medulloblastoma: What Constitutes Low-risk and How Low Can One Go?

February 27, 2023

The definition of low-risk WNT-pathway medulloblastoma may need to be refined in light of recent clinical data and newer biological information.” BUFFALO, NY- February 27, 2023 – A new research... read more

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Oncotarget | Oncogenic Driver FGFR3-TACC3 Requires 5 Coiled-coil Heptads for Activation and Disulfide Bonds for Stability

February 23, 2023

Together, this work highlights the need to investigate different breakpoints of fusion proteins, as they may potentially lack the necessary biological activity required for oncogenesis, ultimately leading to misidentification of... read more

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Oncotarget | Extreme Phenotype Approach Identifies Rare ATR Variants as Potential Male Breast Cancer Susceptibility Alleles

February 21, 2023

Basic functions of ATR classify it in the category of tumor suppressor genes but further studies show that its role is more complex in the context of cancer.” BUFFALO,... read more