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Extracellular Matrix and Tumor-Immune Interactions: Challenges & Opportunities

November 12, 2024

This review explores our current understanding of how ECM geometry influences the behaviors of both immune cells and tumor cells, which in turn impacts treatment efficacy and cancer evolutionary progression.”... read more

Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe

Oncotarget

Behind the Study: Molecular Chaperones & Tumor Suppressor Stability

October 24, 2024

Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe from SUNY Upstate Medical University (Syracuse, NY) discuss a review they co-authored that was published by Oncotarget in Volume 15, entitled “Molecular... read more

Oncotarget

Molecular Chaperones: Guardians of Tumor Suppressor Stability

October 16, 2024

Focusing on the holistic lifecycle of these proteins reveals commonalities between the widely diverse group of tumor suppressors, which is invaluable to inform therapy development for multiple cancers.”BUFFALO, NY-... read more

Oncotarget

Zika Virus as a Treatment for Brain Cancer: A Systematic Review

October 9, 2024

Despite limited human evidence, it shows potential benefits.”BUFFALO, NY- October 9, 2024 – A new review was published in Oncotarget's Volume 15 on September 30, 2024, entitled, “Zika virus and... read more

Oncotarget

FOXM1 and PD-L1 in CDK4/6-MEK Resistance in Nerve Tumors

October 1, 2024

We suggest that future therapeutic strategies targeting the oncogenic network of CDK4/6, MEK, PD-L1, and FOXM1 represent exciting future treatment options for MPNST patients.”BUFFALO, NY- October 1, 2024 –... read more

Oncotarget

The Targeting of WNT5B and WNT10B in Osteosarcoma

September 4, 2024

As there is controversy over whether we should use WNT activators or WNT inhibitors to treat osteosarcoma, we hypothesize that it depends on whether the canonical or non-canonical pathways are... read more

Oncotarget

Role of the Gut Barrier in Colorectal Cancer Treatment

August 19, 2024

Herein we discuss how gut microbiota and microbial metabolites regulate basal inflammation levels in the gut and the healing process of the bowel after surgery.”BUFFALO, NY- August 19, 2024 –... read more

Oncotarget

Systemic AL Amyloidosis: Current Approach and Future Direction

May 5, 2023

AL amyloidosis is a fatal disease and systemic therapy is required to prevent deposition of amyloid in other organs and prevent progressive organ failure.”BUFFALO, NY- May 5, 2023 – A... read more

Dr. Glenn Simmons Jr. and Dr. Stefani Thomas

Oncotarget

Behind the Study: Targeting Lipid Metabolism in Treatment of Ovarian Cancer

September 12, 2022

Dr. Glenn Simmons Jr. from Cornell University College of Veterinary Medicine, and Dr. Stefani Thomas from University of Minnesota School of Medicine, detail a recent review they co-authored that was... read more

Oncotarget

Behind the Study: IGF-pathway Biomarkers and Lung Cancer

June 14, 2022

Dr. Alexander Pohlman from Rush Medical College, Rush University Medical Center, Chicago, IL, describes a recent review published by Oncotarget that he co-authored entitled, “The role of IGF-pathway biomarkers in... read more